The experimental study on the effects of various ulcer-treating pharmaceuticals, basic aluminum , sucrose sulfate,
atropine sulfate, sodium bicarbonate and propantheline bromide, was performed with .the use of ulcer-induced Shay rats under the purpose of comparative observation of suppressive effect and alternation in gastric juice picture by administration of the antacid, anticholinergic drugsand pepsin inhibitor.
The following results were obtained:
1. The ulcer inducement was observed in all cases of the control group and groups of atropine sulfate and sodium bicarbonate administrations, in the group.of propantheline bromide administration at the occurence rate of 70%, and in the group of basic aluminum sucrose sulfate administration at the rate of :55% indicative: of the lowest occurence.
2. The amount of gastric secretion revealed the decrease in the propantheline bromide, gro up as comparedwith the control´ group, indicating 10.4±1.30m1, and there was no difference of significance in the other groups on the, amount determination.
3. In pH check-up of gastric juice, there could- be observed higher pH in the all drug-administered groups than in the control group indicating pH 0, 98±0.27. It revealed highest pH 5. 16±0.,69, , of . gastric juice in basic aluminum sucrose sulfate group, and secondly high pH in atropine sulfate group.
4. In determination of total acidity and free HCL of gastric juice, there could be demonstrated the lowest total acidity in basic aluminum sucrose sulfate group, and there were the atropine sulfate group and sodium bicarbonate group in the decreasing order of acidity. And . it showed no free HCI at all in basic aluminum sucrose sulfate group, and the striking decrease of, free HCI in atropine sulfate group as compared :with the control group indicating 64.1±16.01 mEq/dl.
5. There could be seen the marked decrease of total protein and mucoprotein in the gastric, juice of basic aluminum sucrose sulfate group in comparison with 564.8±6. 13 mg/dl of total protein and 143?35.99 mg/dl of mucoprotein in the control group, and rather increased amount of total protein and mucoprotein in atropine sulfate and propantheline bromide groups.
6. There could be noted the remarkable diminution of peptic activity and co´ centration in basic aluminum sucrose sulfate group as compared with the control group indicating 1935.5?564.23 unit/ml and 0.3137±0.0855 mg/ml, and the next order of pepsin decrease was seen in sodium bicarbonate group.
In brief, there could be observed striking decreases in total acidity, free HCI, total protein, mucoprotein and peptic activity in the gastric juice and remarkable diminution of ulcer inducement of the group of basic aluminum sucrose sulfate administration as compared with the gastric juice picture of the control group except an equivalence in the amount of gastric secretion.
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